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Modafinil vs Armodafinil: Understanding the two potent cognitive enhancers
First came Adrafinil, which the liver then converts into Modafinil. Researchers replicated the process, and Modafinil was directly synthesized. Modafinil was then further split by isolating the R-enantiomer. Armodafinil came into existence.
Modafinil and Armodafinil are two of the most popular cognitive enhancers in use. Both are incredibly similar and both have pros and cons. This makes it difficult for some users to choose between Modafinil vs Armodafinil.
What is Modafinil?
Modafinil is a wakefulness-enhancing substance. Doctors prescribe it for narcolepsy, obstructive sleep apnea and other sleep-related disorders. [R] Still, the vast majority of users use it for improved performance on long and complex tasks.
Entrepreneurs, professionals, students and athletes use Modafinil for its potent enhancing effects.
Its most noticeable enhancements include:
An overview of 24 studies of Modafinil was conducted in 2015 by Dr. Battleday and Dr. Brem from the University of Oxford and Harvard Medical School. They’ve concluded that Modafinil is the first example of a smart drug that can genuinely help people with tasks such as exam preparation. [R]
A study was made on 41 people who were experiencing a 64-hour long period of sleep deprivation. Doctors found that a 300 mg dose of Modafinil noticeably improved cognition when compared to a placebo. An interesting thing had been noticed. Those who had taken 20 mg of amphetamine scored similar results in cognition, fatigue and mood to those who had taken 300 mg. [R]
Indeed, Modafinil isn’t as powerful as amphetamines. Still, user reports and studies hint that it’s just as effective as a cognitive enhancer. People in the US are struggling with Adderall (dextroamphetamine + levoamphetamine) addiction. Many have either switched completely to Modafinil or use it to ease withdrawal symptoms. [R]
What is Armodafinil?
Armodafinil is an enantiopure derivative of Modafinil. It’s made from the isolation of the R-enantiomer of the popular smart drug.
Armodafinil was initially produced by pharmaceutical company Cephalon Inc. as Nuvigil. It has approved by the FDA in 2007 and it’s available online as Waklert or Artvgil.
Most studies have been conducted on Modafinil and a lot of what’s known about Armodafinil stems from user reports.
Opinions are diverse when it comes to Modafinil vs Armodafinil, which is perfectly normal. The uniqueness of one’s brain chemistry and mental state can greatly influence one’s experience.
The science behind Modafinil and Armodafinil
Both Modafinil and Armodafinil act in a subtle, yet complex way. They modulate glutamate, dopamine, norepinephrine, serotonin, orexin, histamine and GABA. These are key neurotransmitters responsible for cognition, mood and energy levels.
Modafinil has two enantiomers: the R-enantiomer and the S-enantiomer.
The R-enantiomer produces most of Modafinil’s desirable effects. This is why isolation was considered by scientists in the first place. [R]
Similarities between Armodafinil and Modafinil
Modafinil and Armodafinil are almost one and the same. Both act on the same neurotransmitters and both are potent in their effects.
The high degree of similarity between the two “afinils” further adds to the subjectivity of choosing between the two.
Key differences of Modafinil vs Armodafinil
Users have reported that Armodafinil creates a cleaner effect than Modafinil.
Armodafinil lasts slightly longer than Modafinil, making it ideal for all-nighters. The half-life of Modafinil lasts around 12 hours, while that of Armodafinil is known to last 15 hours.
In spite of its longer half-life, people find it easier to fall asleep.
Armodafinil is better for repetitive tasks that don’t need a lot of thinking to pull through.
Modafinil is less expensive than Armodafinil, mainly because it’s been around longer. Armodafinil is not as available as Modafinil to buy online.
Modafinil vs Armodafinil: Do we have a winner?
Most people buy Modafinil online before trying Armodafinil, simply because it’s more popular than the latter.
Opinions are mixed among those who have tried both Armodafinil and Modafinil. You’ll have to try both smart drugs for yourself if you want to see which one works best.
The battle between Armodafinil vs Modafinil can be viewed as a draw. Subjectivity is the “victor”.
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Both Armodafinil and Modafinil are incredibly effective. Each one will help you achieve your goals and perform better on your tasks.